Both the standard cast and their complex Tainted counterparts.
In The Binding of Isaac , content is gated behind specific "secrets" (achievements). A 100% save file—often referred to as a save—provides:
Repentance is the final, massive expansion to the Isaac saga, adding hundreds of items, dozens of bosses, and the incredibly difficult "Tainted" characters. Unlocking everything legitimately can take upwards of 600 to 1,000 hours. Here is everything you need to know about finding, installing, and using a complete save file. Why Use a 100% Save File?
Every entry filled for the completionists who just want to see a "finished" menu.